Clasp: Common Lisp using LLVM and C++ for Molecular Metaprogramming
Overview
Christian Schafmeister's Google Tech Talk on designing spiroligomer molecules and building Clasp, a Common Lisp on LLVM that interoperates with C++, to program molecular design. It covers the chemistry, automatic differentiation for force fields, and how the compiler is built.
On Hacker News
HN repeatedly cites it as a striking example of Common Lisp used to push the frontier of science, and as one of the most inspiring tech talks.
Topics
Sources
Video by Google TechTalks, played through YouTube.
Data and selection notes
HN summaries and labels may contain AI errors. HN dates refer to discussions, not video publication.
HN Library: HackerTube export (2026-10-31) and open-index/hacker-news. Upstream summaries and classifications may contain AI errors.
Views, duration and playback status refresh separately from the published catalog. When an update fails, existing data remains visible.
Selection checks
- SaaS & AI candidates: Topic keywords do not match
- Editor-approved picks: Editorial review is required
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