Ron Vale (UCSF, HHMI) 1: Molecular Motor Proteins

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shagie · 2024-02 · Recommendation

[LINK] I didn't realize there was also a Powering the Cell: Mitochondria video. The classic one narrated - [LINK] One of my pandemic YouTube binges was watching Ron Vale videos about kinesin and dynein. [VIDEO] [LINK] [LINK] And searching for Ron Vale will bring a number of other videos about molecular machines.

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dopylitty · 2021-09 · Recommendation

If you think that’s cool you might also like to see the motor proteins that walk along inside our cells. There are a few types including the ones that make muscles work. Kinesin is fun because it has little legs made of proteins. It gloms onto big bubbles of stuff inside the cell and carries them along pathways to their destination. Chemical reactions cause the proteins to fold in the right way to take each step. This shows how they look. [LINK] This explains the mechanisms that they use to walk. [VIDEO]

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dghughes · 2016-11 · Recommendation

When I see stuff like this I have to say I am amazed at how precise some drugs are. Somewhat related I was watching a video about protein motors and how they work. They are small structures that walk on microtubules (as mentioned in the Alzheimer's article) inside cells. There are many types but some walk using hinged protein feet. The narrator explained how his team invented a drug that helped to make one step in that process better. They made the hinge part of the foot work normally giving it more strength. It was a single phosphate molecule added to this step. It was incredible to think one small part of a protein motor the "ankle" part of the foot of that one protein motor on a microtubule inside a single cell had some help. I explained it horribly here is the video [VIDEO] edit: phosphate not sulphur

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