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I Genetically Engineered *MYSELF* to Fix Lactose Intolerance

The Thought Emporium · 640.2K views · 2018-02-13 · 18:33

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Overview

The Thought Emporium's host describes making and taking a DIY gene therapy to treat his own lactose intolerance. It uses an AAV virus to deliver DNA coding for the lactose-digesting enzyme, made with biohacker Gabriel Licina's help.

On Hacker News

HN keeps citing it as the standard example of accessible DIY gene engineering and self-experimentation, in threads on gene therapy, CRISPR and biohacking.

Recommended by 8 HN people across 7 months · HN mentions 2018–2026

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What people said

mrtksn · 2023-07 · Strong recommendation

Interesting is understatement, it's a channel which is one of the closer ones to hard science on the hard science - pop science spectrum and still having more than a million subscribers. Some outstanding videos IMHO: The channel owner applies himself a gene therapy to fix his lactose intolerance. [VIDEO] How exactly the Covid Tests work: [LINK] Growing Human Neurons Connected to a Computer [LINK] Especially the Covid test video was eye opening against the conspiracy theorist propaganda during the pandemic because knowing how tests actually work on practical level makes you see through the claims effort free.

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Confiks · 2021-07 · Strong recommendation

You mean like the guy who in 2018 claimed to have cured himself of lactose intolerance for a while by ingesting a gene-modifying Adenolike virus? [1] No fancy lipid-bubble-riding mRNA necessary. The rest of the channel is pure biohacking gold. The yeast spider silk video is much recommended. [1] [VIDEO]

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bschne · 2022-01 · Recommendation

What got me started was probably this from "The Thought Emporium", and other videos on his channel: [VIDEO] (obvious don't try this at home disclaimer). What I'm reading right now is "Molecular Biology of the Cell" — it's a dense textbook and I'm taking my time, so only about two chapters in, but I love how it focuses on a lot of fundamental principles and occasionally points out astonishing facts. There's also this series which might be a nice, casual primer: [LINK] James Somers also lists some other books in his post I linked to above, might be worth checking out.

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Sources

Video by The Thought Emporium, played through YouTube.

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