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Claude Opus 4.6 vs GPT-5.3 Codex

Greg Isenberg · 54.3K views · 2026-02-06 · 48:55

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I sit down with Morgan Linton, Cofounder/CTO of Bold Metrics, to break down the same-day release of Claude Opus 4.6 and GPT-5.3 Codex. We walk through exactly how to set up Opus 4.6 in Claude Code, explore the philosophical split between autonomous agent teams and interactive pair-programming, and then put both models to the test by having each one build a Polymarket competitor from scratch, live and unscripted. By the end, you'll know how to configure each model, when to reach for one over the other, and what happened when we let them race head-to-head.

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