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The IGF-1 Trade-Off: Performance vs. Longevity

FoundMyFitness · 516.7K views · 2013-09-04 · 5:17

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Overview

A short FoundMyFitness explainer on the trade-off between growth hormone/IGF-1 and longevity. Higher IGF-1 helps muscle and cognition, while lower levels are linked to longer lifespan and stress resistance.

On Hacker News

Linked in discussions of diet, aging and cancer as a quick summary of how IGF-1 and mTOR growth signaling cut against longevity.

Recommended by 1 HN people across 1 months · HN mentions 2014–2022

Topics

Fitness, sleep & longevityMedicine & infectious disease
Search by tags
igf-1growth hormoneagingcaloric restrictionmtor

What people said

dpatrick86 · 2014-10 · Recommendation

Speaking to your question about "what the long term effects of these drugs are": My wife put together a together a pretty interesting video about the "faustian bargain" which is IGF-1 (used as a proxy measure for growth hormone)... video is replete with examples of the effects of low IGF-1/GH or high IGF-1/GH both in animal models and humans. One of the more interesting points in the video is the fact that people with polymorphisms that make their IGF-1 receptor experience some slight loss of function actually live longer (in general). [VIDEO] The video also links to an article which has a bibliography if you're interested.

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loudtieblahblah · 2022-03 · Reference

[LINK] [LINK] Its pretty well know mtor/igf-1 stimulates growth. All growth. This is great for youth. Not so much for aging. [VIDEO]

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femiagbabiaka · 2021-04 · Reference

1. Bigger groups === more and better data. I didn't know anyone growing up who was interested in ketogenic or carnivorous diets, now it's much more common. 2. Huge difference between the diet of a westerner following carnivore and traditional tribal carnivorous diets 3. The Inuits weren't particularly healthy, I'm not sure why their diet matters: [LINK] 4. And most importantly, there's a lot of research showing that high levels of IGF-1 associated with diets high in red meat are not good for longevity: [VIDEO]

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Sources

Video by FoundMyFitness, played through YouTube.

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